Aptra Synthesis

List of Intermediates

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Chemical Name

2-(4-(2-hydroxyethyl)phenyI)-2-Methylpropanoic acid

CAS No.

552301—45—8

End Use

Bilastin

(R)-4-PropyIdihydrofuran-2(3H)-one

63095—51—2

Brivaracetam

2-(4-Cyano phenyl amino) acetic acid

42288—26—6

Dabigatran

4-(methyIamino)-3-nitrobenzoic acid

41263—74—5

Dabigatran

4-Amino Benzonitrile

873—74—5

Dabigatran

Ethyl 3-(Pyridin-2yl amino) Propionate

103041—38—9

Dabigatran

Ethyl -3[3-Amino-4-methyl amino)-N(2-PyridyI) benzamide] propanoate

212322—56—0

Dabigatran

Ethyl-3(2-(t(4-cyanophenyI) amino) methyl)-1-methyl-n-(pyridine-2-yI) 1H-Benzo[D] imidazoIe-5-carboxamido) propanoate

211915—84—3

Dabigatran

Ethyl-3-(4-(methyIamino)-3-Nitro-N-(Pyridin-2-yI)benzamide) propanoate

429659—01—8

Dabigatran

2-ChIoro-1,3-bis(dimethyIamino)trimethinium hexafluorophosphate

291756—76—8

Etoricoxib

4- Methyl sulphonyl phenyl acetic acid

90536—66—6

Etoricoxib

Ketosulfone

221615—75—4

Etoricoxib

Chemical Name

Methyl-6-methyInicotinate

CAS No.

5470-70-2

End Use

Etoricoxib

3-[2-(3-ChIorophenyI)ethyI]-2-pyridinecarbonitriIe

31255—57—9

Loratadine

N-methyl loratadine

38092—89—6

Loratadine

(2,4,5-trifIuorophenyI)acetic acid

209995—38—0

Sitagliptin

(3R)-3-Amino-1-[3-(trifIuoromethyI)-5,6,7,8-tetrahydro-1,2,4-triazoIo [4,3-a]pyrazin-7-yI]-4-(2,4,5-trifIuorophenyI)butan-1-one

486460—32—6

Sitagliptin

2,4,5-TrifIuoro-§-oxo-benzenebutanoic Acid Methyl Ester

769195—26—8

Sitagliptin

3—(Trifluoromethyl)—5,6,7,8—tetrahydro—[1,2,4]triazoIo[4,3-a]pyrazine Hydrochloride

762240—92—6

Sitagliptin

Sitagliptin keto amide

764667—65—4

Sitagliptin

1-(7,8-Dinitro-1,2,4,5-tetrahydro-3H-1,5-methanobenzo[d] azepin-3-yI)ethan-1-one

1213782—02—5

Varenicline

N-methyl-4-ChIoropiperidine

5570—77—4

Loratadine

Chemical NameCAS No.End Use
2-(4-(2-hydroxyethyl)phenyI)-2-Methylpropanoic acid552301—45—8Bilastin
(S)-Methyl 2-(2-chlorophenyl)-2-((2-(thiophen-2-yl)ethyl)amino)acetate hydrochloride.141109-19-5Clopidogrel Bisulphate
(R)-4-PropyIdihydrofuran-2(3H)-one63095—51—2Brivaracetam
2-(4-Cyano phenyl amino) acetic acid42288—26—6Dabigatran
4-(methyIamino)-3-nitrobenzoic acid41263—74—5 Dabigatran
4-Amino Benzonitrile873—74—5Dabigatran
Ethyl 3-(Pyridin-2yl amino) Propionate103041—38—9Dabigatran
Ethyl -3[3-Amino-4-methyl amino)-N(2-PyridyI) benzamide] propanoate212322—56—0Dabigatran
Ethyl-3(2-(t(4-cyanophenyI) amino) methyl)-1-methyl-n-(pyridine-2-yI) 1H-Benzo[D] imidazoIe-5-carboxamido) propanoate211915—84—3Dabigatran
Ethyl-3-(4-(methyIamino)-3-Nitro-N-(Pyridin-2-yI)benzamide) propanoate429659—01—8Dabigatran
2-ChIoro-1,3-bis(dimethyIamino)trimethinium hexafluorophosphate291756—76—8Etoricoxib
4- Methyl sulphonyl phenyl acetic acid90536—66—6Etoricoxib
Ketosulfone221615—75—4Etoricoxib
Methyl-6-methyInicotinate5470-70-2Etoricoxib
3-[2-(3-ChIorophenyI)ethyI]-2-pyridinecarbonitriIe31255—57—9Loratadine
N-methyl loratadine38092—89—6Loratadine
(2,4,5-trifIuorophenyI)acetic acid209995—38—0Sitagliptin
(3R)-3-Amino-1-[3-(trifIuoromethyI)-5,6,7,8-tetrahydro-1,2,4-triazoIo [4,3-a]pyrazin-7-yI]-4-(2,4,5-trifIuorophenyI)butan-1-one486460—32—6Sitagliptin
2,4,5-TrifIuoro-§-oxo-benzenebutanoic Acid Methyl Ester769195—26—8Sitagliptin
3—(Trifluoromethyl)—5,6,7,8—tetrahydro—[1,2,4]triazoIo[4,3-a]pyrazine Hydrochloride762240—92—6Sitagliptin
Sitagliptin keto amide764667—65—4Sitagliptin
1-(7,8-Dinitro-1,2,4,5-tetrahydro-3H-1,5-methanobenzo[d] azepin-3-yI)ethan-1-one1213782—02—5Varenicline
N-methyl-4-ChIoropiperidine5570—77—4Loratadine

Disclaimer

No information in this catalog – including any reference to any product or service – constitutes an offer for sale, or be construed as representing an offer for sale. Products protected under valid patents are not offered or supplied for commercial use. However, the research quantities of such products may be offered for the purpose of regulatory submissions, wherever such regulatory exemptions exist. The buyers should make their independent evaluation of the patent scenario for their respective markets and will be responsible for all patent related liabilities. Products protected under valid patents in India are not available for commercial use but would be available for Section 107A purposes.